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We generally recommend puppies receive Distemper/Parvo (DHPP) vaccines every 3 weeks until they are over 16 weeks of age. Leptospirosis (Lepto) vaccine is recommended based on lifestyle risk. After 12 weeks and closer to 16 weeks, we administer the rabies vaccine and recommend the Bordetella (kennel cough) vaccine at that time. In addition to vaccines, puppies need to start heartworm prevention and flea/tick prevention at about 8 weeks of age.